From Klinefelter Syndrome to High Grade Aneuploidies: Expanding the Gene-dosage Effect of Supernumerary X Chromosomes.
Matteo SpazianiFrancesco CarlomagnoChiara TarantinoFrancesco AngeliniRoberto PaparellaLuigi TaraniCarolina PutottoRoberto BadagliaccaCarlotta PozzaAndrea M IsidoriDaniele GianfrilliPublished in: The Journal of clinical endocrinology and metabolism (2024)
The increase in the number of extra-Xs is associated with a "dose-dependent" progressive impairment in steroid producing glands, thyroid function, cardiac structure, and performance.