Arsenic trioxide increases apoptosis of SK-N-BE (2) cells partially by inducing GPX4-mediated ferroptosis.

Chuchu FengYu WuYantao ChenXilin XiongPeng LiXiaomin PengChunmou LiWenjun WengYafeng ZhuDunhua ZhouYang Li

Published in: Molecular biology reports (2022)

Our study revealed that ATO may induce ferroptosis in neuroblastoma cell SK-N-BE (2) by facilitating the downregulation of GPX4, ultimately resulting in iron-dependent oxidative death.

Keyphrases

cell death
cell cycle arrest
induced apoptosis
single cell
endoplasmic reticulum stress
oxidative stress
signaling pathway
cell proliferation
drinking water
cell therapy
stem cells
heavy metals
risk assessment
mesenchymal stem cells