Identification of Novel Loci Shared by Juvenile Idiopathic Arthritis Subtypes Through Integrative Genetic Analysis.

Jin LiYun R LiJoseph T GlessnerJie YangMichael E MarchCharlly KaoCourtney N VaccaroJonathan P BradfieldJunyi LiFrank D MentchHui-Qi QuXiaohui QiXiao ChangCuiping HouDebra J AbramsHaijun QiuZhi WeiJohn J ConnollyFengxiang WangJames SnyderBerit FlatøSusan D ThompsonCarl D LangefeldBenedicte A LieJane E MunroCarol A WisePatrick M A SleimanHakon H Hakonarson

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

This study identified novel genetic loci shared by JIA subtypes. Our findings identified candidate mechanisms underlying JIA subtypes and candidate targets with drug repurposing opportunities for JIA treatment.

Keyphrases

juvenile idiopathic arthritis
genome wide
disease activity
genome wide association study
dna methylation
genome wide association
rheumatoid arthritis
systemic lupus erythematosus
emergency department
drug induced