A Single Intraperitoneal Injection of Endotoxin Changes Glial Cells in Rats as Revealed by Positron Emission Tomography Using [11C]PK11195.
Miho OtaJun OguraShintaro OgawaKoichi KatoHiroshi MatsudaHiroshi KunugiPublished in: Nuclear medicine and molecular imaging (2018)
Changes in activity of glial cells induced by the intraperitoneal injection of LPS were detected in vivo by [11C]PK11195 PET. Intraperitoneal injection of LPS is known to induce depression, and further studies with [11C]PK11195 PET would clarify the relationships between neuroinflammation and depression.
Keyphrases
- positron emission tomography
- computed tomography
- induced apoptosis
- pet ct
- cell cycle arrest
- pet imaging
- depressive symptoms
- ultrasound guided
- inflammatory response
- traumatic brain injury
- signaling pathway
- cell death
- lipopolysaccharide induced
- sleep quality
- cognitive impairment
- brain injury
- spinal cord injury
- cell proliferation
- pi k akt
- subarachnoid hemorrhage