The association between warfarin usage and international normalized ratio increase: systematic analysis of FDA Adverse Event Reporting System (FAERS).
Robert MorrisMegan ToddNicole Zapata AponteMilagros SalcedoMatthew BrucknerAlfredo Suarez GarciaRachel WebbKun BuWeiru HanFeng ChengPublished in: The journal of cardiovascular aging (2023)
The risk of elevated INR increased as patient age increased, particularly among those older than 80. Elevated INR frequently co-presented with decreased hemoglobin, drug interactions, hematuria, asthenia, and fall in patients taking warfarin. This effect may be less pronounced in women due to the procoagulatory effects of estrogen signaling. Multiple possible DDIs were identified, including acetaminophen, ramipril, and furosemide.
Keyphrases
- end stage renal disease
- atrial fibrillation
- venous thromboembolism
- newly diagnosed
- ejection fraction
- direct oral anticoagulants
- chronic kidney disease
- peritoneal dialysis
- polycystic ovary syndrome
- prognostic factors
- case report
- physical activity
- emergency department
- type diabetes
- liver injury
- oral anticoagulants
- middle aged
- estrogen receptor
- community dwelling