Prevalence of germline mutations in the TP53 gene in patients with early-onset breast cancer in the Mexican population.
Lenny N Gallardo-AlvaradoMaría Teresa Tusié-LunaMaría Isabel Tussié-LunaJosé Díaz-ChávezYayoi X SeguraEnrique Bargallo-RochaCynthia VillarrealLuis A Herrera-MontalvoEnrique M Herrera-MedinaDavid Cantu-de LeonPublished in: BMC cancer (2019)
Among Mexican BC patients diagnosed at a young age, we identified a high proportion with germline mutations in the TP53 gene. All patients with the TP53 mutations had a family history suggestive of LFS. To establish the clinical significance of the VUS found, additional studies are needed. Pathogenic variants of TP53 may explain a substantial fraction of BC in young women in the Mexican population. Importantly, none of these mutations or other pathological variants in TP53 were found in the healthy control group.