CSF Proteomics in Patients With Progressive Supranuclear Palsy.

Amy WiseJingyao LiMai YamakawaJoseph LoureiroBrant PetersonKathleen WorringerRajeev SivasankaranJose-Alberto PalmaLaura Mitic Hilary W HeuerArgentina Lario-LagoAdam M StaffaroniAnnie ClarkJack TaylorPeter A LjubenkovLawren VandeVrede Lea Tenenholz Grinberg Salvatore Spina William W Seeley Bruce L Miller Bradley F Boeve Bradford C DickersonMurray GrossmanIrene Litvan Alexander Y Pantelyat Maria Carmela TartagliaZihan ZhangAnne-Marie A WillsJessica RexachJulio C RojasAdam L Boxernull null

Published in: Neurology (2024)

Axon guidance pathway proteins and several other molecular pathways are downregulated in PSP, compared with controls. Proteins in these pathways may be useful targets for biomarker or therapeutic development.

Keyphrases

multiple sclerosis
mass spectrometry
single molecule
label free
cerebrospinal fluid