Impacts of Posttransplant Cyclophosphamide Dose on Graft-versus-leukemia Effects via HLA-B Leader in HLA-haploidentical Peripheral Blood Stem Cell Transplantation.

Makoto MoriguchiKentaro IdoHiroshi OkamuraMika NakamaeKazuki SakatokuYosuke MakuuchiMasatomo KunoTeruhito TakakuwaAsao HiroseMitsutaka NishimotoYasuhiro NakashimaHideo KohMasayuki HinoHirohisa Nakamae

Published in: Acta haematologica (2024)

Our findings suggest that the effect of the patient HLA-B leader genotype is modified by the PTCy dose, providing immunological insight into the PTCy dosage and supporting further studies to investigate the underlying mechanisms.

Keyphrases

stem cell transplantation
high dose
peripheral blood
low dose
bone marrow
acute myeloid leukemia
case report
cord blood