Tumor-related molecular determinants of neurocognitive deficits in patients with diffuse glioma.
Emma van KesselSharon BerendsenAnniek E BaumfalkHema VenugopalEva A KrijnenWim G M SplietWim van HeckeFabrizio GiulianiTatjana SeuteMartine J E van ZandvoortTom Jan SnijdersPierre A RobePublished in: Neuro-oncology (2022)
Molecular characteristics of glioma can be independent determinants of patients' cognitive functioning. This suggests that besides tumor volume, location, and histological grade, variations in glioma biology influence cognitive performance through mechanisms that include perturbation of neuronal communication. These results pave the way towards targeted cognition improving therapies in neuro-oncology.