Bilateral versus unilateral botulinum toxin injections for chronic anal fissure: a randomised trial.
S A PilkingtonRahul BhomeR E WelchF KuC WardenS HarrisJ HicksC RichardsonT C DuddingJ S KnightA T KingA H MirnezamiN E BeckP H NicholsK P NugentPublished in: Techniques in coloproctology (2018)
Injection-related pain was similar in bilateral and unilateral injection groups. Unilateral injection was as effective as bilateral injections in healing and improving fissure pain without any deterioration in continence.