Sc(OTf) 3 -Catalyzed Domino C-C/C-N Bond Formation of Aziridines with Quinones via Radical Pathway.

Kshitiz VermaManmath MishraPrabhat Kumar MaharanaHemanga BhattacharyyaSharajit SahaTharmalingam Punniyamurthy

Published in: Organic letters (2023)

Sc(III)-catalyzed domino C-C and C-N bond formation of N -sulfonyl aziridines with quinones has been accomplished to furnish functionalized indolines at a moderate temperature. The umpolung reactivity of aziridines, radical pathway, mild reaction conditions, substrate scope, and coupling of drug molecules in a postsynthetic application are the important practical features.

Keyphrases

room temperature
electron transfer
quantum dots
high intensity
emergency department
metal organic framework
amino acid
adverse drug
solid phase extraction