Growth Hormone Accelerates Recovery From Acetaminophen-Induced Murine Liver Injury.

Elissa EvertonMercedes Del Rio-MorenoCarlos Villacorta-MartinPushpinder Singh BawaJonathan Lindstrom-VautrinHiromi MuramatsuFatima RizviAnna R SmithYing TamNorbert PardiRhonda KinemanDavid J Waxman Valerie Gouon-Evans

Published in: bioRxiv : the preprint server for biology (2023)

Our study demonstrates a sexually dimorphic liver repair advantage in females following APAP overdose, leveraged by establishing GH as an alternative treatment, delivered either as recombinant protein or mRNA-LNP, to potentially prevent liver failure and liver transplant in APAP-overdosed patients.

Keyphrases

liver injury
drug induced
growth hormone
liver failure
end stage renal disease
chronic kidney disease
newly diagnosed
ejection fraction
prognostic factors
peritoneal dialysis
binding protein
endothelial cells
oxidative stress
high glucose
small molecule
protein protein
patient reported