Lysine oxidase exposes a dependency on the thioredoxin antioxidant pathway in triple-negative breast cancer cells.

Olga E ChepikovaDmitry MalinElena StrekalovaElena V LukashevaAndrey A ZamyatninVincent L Cryns

Published in: Breast cancer research and treatment (2020)

LO exposes a redox vulnerability of TNBC cells to TXNRD inhibition by rendering tumor cells dependent on the thioredoxin antioxidant pathway for survival.

Keyphrases

breast cancer cells
oxidative stress
induced apoptosis
anti inflammatory
cell cycle arrest
climate change
endoplasmic reticulum stress
cell death
free survival
amino acid