Parvalbumin interneuron-derived tissue-type plasminogen activator shapes perineuronal net structure.

Matthieu LépineSara DouceauGabrielle DeviennePaul PrunottoSophie LenoirCaroline RegnauldElsa PouettreJuliette PiquetLaurent LebouvierYannick HommetEric MaubertVéronique AginBertrand LambolezBruno CauliCarine AliDenis Vivien

Published in: BMC biology (2022)

We demonstrate that tPA released from FS-PV interneurons in the central nervous system reduces PNN density through CSPG degradation. The discovery of this tPA-dependent PNN remodeling opens interesting insights into the control of brain plasticity.

Keyphrases

small molecule
resting state
white matter
high throughput
cerebrospinal fluid
functional connectivity
cerebral ischemia
brain injury