TLR7 is expressed by support cells, but not sensory neurons, in ganglia.

Becky J ProskocilKarol WaiKatherine M LeboldMason A NorgardKatherine A MichaelisUbaldo De La TorreMadeline CookDaniel L MarksAllison D FryerDavid B JacobyMatthew G Drake

Published in: Journal of neuroinflammation (2021)

TLR7 is expressed by macrophages and satellite glial cells, but not neurons in sensory ganglia suggesting TLR7's neuromodulatory effects are mediated indirectly via activation of neuronally-associated support cells, not through activation of neurons directly. Our data also suggest TLR7's primary role in neuronal tissues is not related to antiviral immunity.

Keyphrases

induced apoptosis
toll like receptor
inflammatory response
cell cycle arrest
immune response
spinal cord
gene expression
cell death
signaling pathway
nuclear factor
machine learning
neuropathic pain
spinal cord injury
big data
blood brain barrier
artificial intelligence
drug induced