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Controlled formation of chitosan particles by a clock reaction.

Guido PanzarasaAlina OsypovaAlba SicherArie BruininkEric R Dufresne
Published in: Soft matter (2018)
Clock reactions allow precise control of chemical composition in the time domain. Such nonlinear chemical systems have recently been introduced to mimic the self-assembly pathways common in living organisms. Here, we demonstrate the use of a clock reaction to trigger the formation of polymeric nanoparticles. By adjusting the delay of a formaldehyde clock reaction, we controlled the precipitation of chitosan to form particles with sizes tunable in a wide range (from about 200 to 600 nm diameter). The chemical structure of chitosan was not significantly perturbed by the clock reagents.
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