G3BP1 knockdown sensitizes U87 glioblastoma cell line to Bortezomib by inhibiting stress granules assembly and potentializing apoptosis.

L F F BittencourtG L Negreiros-LimaL P SousaA G SilvaI B S SouzaR I M A RibeiroM F DutraR F SilvaA C F DiasF M SorianiW K MartinsLucas Felipe Fernandes Bittencourt

Published in: Journal of neuro-oncology (2019)

Our data suggest G3BP1 knockdown diminishes SG formation and stimulates BZM-induced apoptosis of U87 cells in vitro, in addition to inhibiting glioblastoma-induced angiogenesis in vivo.

Keyphrases

induced apoptosis
signaling pathway
endoplasmic reticulum stress
oxidative stress
diabetic rats
pi k akt
cell cycle arrest
high glucose
endothelial cells
multiple myeloma
electronic health record
vascular endothelial growth factor
drug induced
big data
stress induced
machine learning
data analysis