18 F-FDG PET, cognitive functioning, and CSF biomarkers in patients with obstructive sleep apnoea before and after continuous positive airway pressure treatment.
Mariana FernandesLuisa MariAgostino ChiaravallotiBarbara PaoliMarzia NuccetelliFrancesca IzziMaria Pia GiambroneRiccardo CameddaSergio BernardiniOrazio SchillaciNicola Biagio MercuriFabio PlacidiClaudio LiguoriPublished in: Journal of neurology (2022)
Cognitive impairment, reduced cerebral glucose consumption, and alterations in CSF biomarkers were observed in OSA patients, which may reinforce the hypothesis of AD neurodegenerative processes triggered by OSA. Notably, cognition and brain glucose consumption improved after beneficial CPAP treatment. Further studies are needed to evaluate the long-term effects of CPAP treatment on these AD biomarkers.
Keyphrases
- positive airway pressure
- obstructive sleep apnea
- sleep apnea
- cognitive impairment
- end stage renal disease
- chronic kidney disease
- computed tomography
- ejection fraction
- white matter
- pet ct
- combination therapy
- metabolic syndrome
- blood pressure
- positron emission tomography
- physical activity
- subarachnoid hemorrhage
- depressive symptoms
- mild cognitive impairment
- replacement therapy
- prognostic factors
- sleep quality
- patient reported