Unveiling the impact of maternal gestational diabetes mellitus on cord blood CD71+ erythroid cell transcriptome.
Min YinYan ZhangXinyu LiXia LiPublished in: Pediatric research (2024)
This study reveals the effects of maternal gestational diabetes mellitus (GDM) on the transcriptome of CD71+ erythroid cells (CECs) in cord blood. It highlights the role of CECs in immunosuppressive function and identifies potential mechanisms linking GDM to adverse outcomes in offspring. This understanding might lead to improved strategies for managing and preventing adverse outcomes in infants born to mothers with GDM.
Keyphrases
- cord blood
- pregnancy outcomes
- single cell
- genome wide
- pregnant women
- rna seq
- birth weight
- induced apoptosis
- gene expression
- gestational age
- cell cycle arrest
- high fat diet
- nk cells
- dna methylation
- cell therapy
- oxidative stress
- low birth weight
- signaling pathway
- metabolic syndrome
- stem cells
- adipose tissue
- cell proliferation
- endoplasmic reticulum stress
- preterm infants
- mesenchymal stem cells
- physical activity
- body mass index
- pi k akt
- weight gain
- skeletal muscle