Multi-omic profiling of simultaneous ductal carcinoma in situ and invasive breast cancer.

Henry G KaplanAlexa K DowdellAnna B BerryRacheli Ben ShimolFred L RobinsonChristopher A CarneyBrian D Piening

Published in: Breast cancer research and treatment (2024)

While most co-occurring DCIS and IBC were mutationally similar and suggestive of a common clonal progenitor, transcriptionally the lesions are highly distinct, with IBC expressing key pathways that facilitate invasion and proliferation. These results are suggestive of additional levels of regulation, epigenetic or other, that facilitate the acquisition of invasive properties during tumor evolution.

Keyphrases

dna methylation
signaling pathway
gene expression
cell migration
single cell
cell fate