Nicotinic-acid derivative BGP-15 improves diastolic function in a rabbit model of atherosclerotic cardiomyopathy.

Dániel PrikszNora LampeArpad KovacsMelissa HerwigMariann BombiczBalazs VargaTician WilisiczJudit SzilvassyAniko PosaRita KissRudolf GesztelyiArnold RadulyReka SzekeresMarcel SiemeZoltan PappAttila TothNazha HamdaniZoltan SzilvassyBela Juhasz

Published in: British journal of pharmacology (2021)

Here we report that BGP-15-treatment improves diastolic function, reduces cardiomyocyte stiffness, and restores titin compliance in a rabbit model of atherosclerotic cardiomyopathy by increasing the activity of the cGMP-PKG axis. As BGP-15 is proven to be safe, it may have clinical value in the treatment of diastolic dysfunction.

Keyphrases

left ventricular
blood pressure
heart failure
oxidative stress
nitric oxide
angiotensin ii