Biased GLP-2 agonist with strong G protein-coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice.

Maria Buur Nordskov GabeLiv von VossJenna Elizabeth HuntSarina GadgaardLaerke Smidt GasbjergJens Juul HolstHannelouise KissowBolette HartmannMette Marie Rosenkilde

Published in: British journal of pharmacology (2023)

G protein-biased GLP-2R agonists with diminished receptor desensitization have superior intestinotrophic effects and may represent improved treatment of intestinal insufficiency including SBS.

Keyphrases

type diabetes
high fat diet induced
binding protein
metabolic syndrome