Impact of prostatic radiation therapy on bladder contractility and innervation.
Alexander C TurnerShelby A PowersMichael R OdomElena S PakKathleen A AshcraftBridget F KoontzJohanna L HannanPublished in: Neurourology and urodynamics (2021)
In a rat model, RT of the prostate and MPG was associated with early changes in MPG Chat gene expression, and bladder cholinergic axon profiles and smooth muscle content which resolved over time. After RT recovery, bladder contractility decreased early and increased by 10 weeks. Long-term changes to the MPG and increased bladder cholinergic axons may contribute to RT-induced bladder dysfunction in prostate cancer survivors.