Prostaglandin E2 secreted from feline adipose tissue-derived mesenchymal stem cells alleviate DSS-induced colitis by increasing regulatory T cells in mice.

Ju-Hyun AnWoo-Jin SongQiang LiSang-Min KimJi-In YangMin-Ok RyuA Ryung NamDong Ha BhangYun-Chan JungHwa Young Youn

Published in: BMC veterinary research (2018)

Our results suggest that PGE2 secreted from fAT-MSC can reduce inflammation by increasing FOXP3+ Tregs in mice model of colitis. Consequently, these results propose the possibility of administration of fAT-MSC to cats with not only IBD but also other immune-mediated inflammatory diseases.

Keyphrases

regulatory t cells
adipose tissue
high fat diet induced
dendritic cells
insulin resistance
oxidative stress
high fat diet
ulcerative colitis
immune response
metabolic syndrome