Value of isolated IgA anti-β2 -glycoprotein I positivity in the diagnosis of the antiphospholipid syndrome.
Vijaya MurthyRohan WillisZurina Romay-PenabadPatricia Ruiz-LimónLaura A Martínez-MartínezShraddha JatwaniPraveen JajoriaAlan SeifGraciela S AlarcónElizabeth PapalardoJigna LiuLuis M ViláGerald McGwinTerry A McNearneyRashmi MagantiPrashanth SunkureddiTrisha ParekhMichael TarantinoEhtisham AkhterHong FangEmilio B GonzalezWalter R BinderGary L NormanZakera ShumsMarius TeodorescuJohn D ReveilleMichelle PetriSilvia S PierangeliPublished in: Arthritis and rheumatism (2014)
Isolated IgA anti-β2 GPI-positive titers may identify additional patients with clinical features of APS. Testing for these antibodies when other antiphospholipid tests are negative and APS is suspected is recommended. IgA anti-β2 GPI antibodies directed to domain IV/V of β2 GPI represent an important subgroup of clinically relevant antiphospholipids.