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A systematic review of craniospinal irradiation for leptomeningeal disease: past, present, and future.

L MaillieL R SalgadoStanislav Lazarev
Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2021)
Despite advances in systemic and radiation therapies, LMD remains a devastating end-stage complication of some malignancies. Treatment-related toxicities can be a significant barrier to CSI delivery. In select patients with LMD, marrow-sparing proton CSI may provide safer palliation of symptoms and prolong survival.
Keyphrases
  • radiation induced
  • small cell lung cancer
  • radiation therapy
  • free survival
  • combination therapy
  • minimally invasive
  • brain metastases