The vertebral 3'-deoxy-3'-18F-fluorothymidine uptake predicts the hematological toxicity after systemic chemotherapy in patients with lung cancer.
Yukihiro UmedaTetsuya TsujikawaMasaki AnzaiMiwa MorikawaYuko WasedaMaiko KadowakiHiroko ShigemiShingo AmeshimaTetsuya MoriYasushi KiyonoHidehiko OkazawaTamotsu IshizukaPublished in: European radiology (2019)
Trial registration: UMIN000027540 KEY POINTS: • The vertebral 18 F-FLT uptake with PET is an independent predictor of the severe hematological toxicity during the first cycle of platinum-doublet chemotherapy. • The 18 F-FLT uptake in L4 vertebral body estimated hematological toxicities better than that in the upper vertebra (Th4, Th8, and Th12). • The evaluation of the amount and activity of hematopoietic cells in the bone marrow cavity using 18 F-FLT PET imaging could provide predictive data of severe hematological toxicities and help determine an appropriate drug combination or dose intensity in patients with advanced malignant diseases.
Keyphrases
- pet imaging
- acute myeloid leukemia
- bone marrow
- tyrosine kinase
- bone mineral density
- induced apoptosis
- oxidative stress
- early onset
- positron emission tomography
- locally advanced
- mesenchymal stem cells
- drug induced
- clinical trial
- computed tomography
- study protocol
- postmenopausal women
- cell cycle arrest
- squamous cell carcinoma
- machine learning
- cell proliferation
- rectal cancer
- endoplasmic reticulum stress
- chemotherapy induced
- pi k akt