Differential mitochondrial genome in patients with Rheumatoid Arthritis.
Kumar Sagar JaiswalShweta KhannaArup GhoshPrasanta PadhanSunil Kumar RaghavBhawna GuptaPublished in: Autoimmunity (2020)
We herein observed an altered mtDNA sequence in immune cells of RA patients and thus a possible role of mitochondrial genome in the development of RA. The observed nucleotide changes in mtDNA control region, RNR2 gene, increased heteroplasmy and mtDNA duplication in RA patients may alter sites for transcription factor binding thereby influencing mtDNA gene expression, as well as copy numbers thereby affecting the mitochondrial proteins and their functions. These changes in mtDNA could be one of the probable reasons among many leading to the progression of RA.
Keyphrases
- mitochondrial dna
- copy number
- end stage renal disease
- gene expression
- rheumatoid arthritis
- transcription factor
- oxidative stress
- ejection fraction
- newly diagnosed
- chronic kidney disease
- genome wide
- peritoneal dialysis
- dna methylation
- disease activity
- prognostic factors
- patient reported outcomes
- systemic lupus erythematosus
- patient reported