Construction of sublingual trilaminated Eszopiclone fast dissolving film for the treatment of Insomnia: Formulation, characterization and In vivo clinical comparative pharmacokinetic study in healthy human subjects.

Mahmoud Hassan TeaimaMohamed YasserNehal ElfarKamel R ShoueirMohamed El-NabarawiDoaa Helal

Published in: PloS one (2022)

F4 had the highest Cmax (39.741 ± 6.785-μg/l) and lower Tmax (1.063 hr) among other formulas and conventional tablets. Therefore, FDFs' technology could increase the therapeutic effect of Eszopiclone.

Keyphrases

endothelial cells
drug delivery
induced pluripotent stem cells
sleep quality
depressive symptoms
allergic rhinitis
gold nanoparticles
high density