High prevalence of short telomeres in idiopathic porto-sinusoidal vascular disorder.

Alexander CoukosChiara SagliettiChristine SempouxMonika HaubitzThomas GreuterLaureane Mittaz-CrettolFabienne MaurerElise Mdawar-BaillyDarius MoradpourLorenzo AlberioJean-Marc GoodGabriela M BaerlocherMontserrat Fraga

Published in: Hepatology communications (2024)

Short and very short telomeres were highly prevalent in patients with idiopathic PSVD, with 31% presenting with variants in telomere-related genes. Telomere biology may play an important role in vascular liver disease development. Clinicians should consider measuring telomeres in any patient presenting with PSVD.

Keyphrases

case report
palliative care
copy number
gene expression