Elevated Extracellular HSP72 and Blunted Heat Shock Response in Severe COVID-19 Patients.
Mariana Kras Borges RussoLucas Stahlhöfer KowalewskiGabriella Richter da NatividadeCarlos Henrique de Lemos MullerHelena Trevisan SchroederPatrícia Martins BockLayane Ramos AyresBernardo Urbano CardosoCaroline ZanottoJulia Tsao ScheinTatiana Helena RechDaisy CrispimLuis Henrique CananiRogerio FriedmanCristiane Bauermann LeitãoFernando GerchmanMauricio KrausePublished in: Biomolecules (2022)
We demonstrated that patients with severe COVID-19 have elevated plasma eHSP72 and that their HSR is blunted, regardless of the presence of diabetes. These results might explain the uncontrolled inflammation and also provide insights on the increased risk in developing type 2 diabetes after SARS-CoV-2 infection.