A Report of Toxin-Induced Graft Injury Following Liver Transplantation for Yellow Phosphorus Poisoning.
Sandeep JasperAbdul Rahman HakeemMukul VijDeepti SachanAkila RajakumarDinesh JothimaniIlankumaran KaliamoorthyMettu Srinivas ReddyMohamed RelaPublished in: Hepatology (Baltimore, Md.) (2021)
Poisoning due to ingestion of yellow phosphorus (YP) containing rodenticide accounts for 17% of all poisoning in India and 0.3% in the USA.(1,2) YP disrupts oxidative phosphorylation and protein synthesis causing acute liver failure (ALF), renal injury, myocarditis, bone-marrow suppression. 70% of ingested toxin rapidly accumulates in liver, with smaller quantities in the heart, kidneys, bones, adrenals, gut.(3) Therapeutic plasma exchange (TPE) has been used anecdotally to reduce the toxin load.(4,5) Liver transplantation (LT) is life-saving for patients progressing to ALF.(2).
Keyphrases
- liver failure
- escherichia coli
- bone marrow
- hepatitis b virus
- end stage renal disease
- newly diagnosed
- ejection fraction
- mesenchymal stem cells
- drug induced
- heart failure
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- diabetic rats
- high glucose
- intensive care unit
- respiratory failure
- patient reported outcomes
- atrial fibrillation
- protein kinase
- aortic dissection