A time-dependent contribution of hippocampal CB1 , CB2 and PPARγ receptors to cannabidiol-induced disruption of fear memory consolidation.

Ana Maria RaymundiThiago R da SilvaAleksander R ZampronioFrancisco S GuimarãesLeandro J Bertoglio Cristina Aparecida Stern

Published in: British journal of pharmacology (2020)

CBD disrupts memory consolidation up to 1 hr after fear conditioning, allowing an extended window of opportunity to mitigate aversive memories after their acquisition. Our results suggest time-dependent participation of anandamide, CB1 , CB2 and PPARγ receptors in the DH, during this process.

Keyphrases

working memory
insulin resistance
physical activity
high glucose
prefrontal cortex
type diabetes
metabolic syndrome
stress induced