Impact of Prophylactic Trimethoprim-Sulfamethoxazole on Clearance of High-Dose Methotrexate in Adult Patients.

Daniel Skoloda Matthew J Newman Haval Norman Jamie E Ziggas Richard F Ambinder

Published in: JCO oncology practice (2024)

Prophylactic TMP/SMX had minimal interaction with HDMTX and does not lead to increased time to clearance or clinically relevant toxicities. Prophylactic TMP/SMX can be safely administered with HDMTX in adult patients.

Keyphrases

high dose
low dose
stem cell transplantation
microbial community
antibiotic resistance genes