Single-cell RNA sequencing reveals pro-invasive cancer-associated fibroblasts in hypopharyngeal squamous cell carcinoma.

Zhimou CaiLin ChenSiyu ChenRuihua FangXiaolin ChenWen-Bin Lei

Published in: Cell communication and signaling : CCS (2023)

mCAFs, acting as the communication center of the HPSCC TME, enhance the invasion ability of HPSCC cells, mobilizing surrounding cells to construct a tumor-favorable microenvironment. Inhibiting mCAF activation offers a new anti-HPSCC therapeutic strategy. Video Abstract.

Keyphrases

single cell
induced apoptosis
squamous cell carcinoma
cell cycle arrest
signaling pathway
rna seq
cell death
high throughput
radiation therapy
anti inflammatory
pi k akt
locally advanced