Eosinophils, basophils and myeloid-derived suppressor cells in chronic Loa loa infection and its treatment in an endemic setting.
Gerrit Marwin BurgerRafiou AdamouRuth KreuzmairWilfrid Ndzebe NdoumbaDorothea Ekoka MbassiAnne Marie Nkoma MouimaCarole Mamgno TabopdaRoukoyath Moyoriola AdegnikaAyong MoreDearie Glory OkwuLia-Betty Dimessa MbadingaCarlos Lamsfus CalleLuzia VeletzkyWolfram Gottfried MetzgerBenjamin MordmüllerMichael RamharterGhyslain Mombo-NgomaAyola Akim AdegnikaRella Zoleko-ManegoMatthew B B McCallPublished in: PLoS neglected tropical diseases (2024)
We demonstrate that both chronic infection and treatment of L. loa microfilaraemia are associated with eosinophil circulation and distinct phenotypical activation markers that might contribute to inflammatory pathways in this setting. In this first ever investigation into MDSC in L. loa infection, we found no evidence for their increased presence in chronic loiasis, suggesting that immunomodulation by L. loa is induced through other pathways.