Impaired Gut-Systemic Signaling Drives Total Parenteral Nutrition-Associated Injury.
Miguel GuzmanChandrashekhara ManithodyJoseph KrebsChristine DentonSherri BesmerPranjali RajalakshmiSonali JainGustavo Adolfo VillalonaAjay Kumar JainPublished in: Nutrients (2020)
We report significant alterations in key hepatobiliary receptors driving gut-systemic signaling in a TPN piglet model. This presents a major advancement to our understanding of TPN-associated injury and suggests opportunities for strategic targeting of the gut-systemic axis, specifically, FXR, TGR5, and EGF in developing ameliorative strategies.
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