Infrequent liver injury from cemiplimab in patients with advanced cutaneous squamous cell carcinoma.
Linnea A SwansonIhab KassabIrene TsungFrancis P WordenRobert J FontanaPublished in: Immunotherapy (2022)
Aim: To describe the incidence and outcomes of liver injury in patients with advanced cutaneous squamous cell carcinoma (cSCC) receiving cemiplimab. Methods: Charts of cSCC patients receiving cemiplimab between 28 September 2018 and 14 July 2020 were reviewed. Liver injury was determined using laboratory criteria, and causality assessment was completed. Results: Of 39 cemiplimab-treated patients, four (10.3%) developed liver injury. Two cases of hepatotoxicity were attributed to immune-mediated liver injury caused by cemiplimab and the two other cases were attributed to other causes. The four patients with liver injury had tumor responses and survival similar to those of the patients without liver injury. Conclusion: Liver injury arising during cemiplimab therapy is mild and infrequent in cSCC patients. Due to its favorable safety profile, cemiplimab should be considered in patients with cSCC and pre-existing liver disease.
Keyphrases
- liver injury
- drug induced
- squamous cell carcinoma
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- adverse drug
- prognostic factors
- peritoneal dialysis
- emergency department
- stem cells
- type diabetes
- risk factors
- insulin resistance
- patient reported outcomes
- adipose tissue
- bone marrow
- weight loss
- mesenchymal stem cells
- skeletal muscle
- smoking cessation
- cell therapy
- replacement therapy