Phosphodiesterase1 inhibitor "Vinpocetine" ameliorates the inflammation, apoptosis and oxidative stress induced by cyclophosphamide in urinary bladder: an experimental study.
Rehab Sabri AbdelrahmanEman Mohamad El NasharMansour Abdullah AlghamdiKhulood Mohammed Al-KhaterReham Ismail TahaPublished in: International urology and nephrology (2022)
This proposes that Vinpo 30 mg/kg may become a promising pharmacological drug to prevent urinary adverse effects in patients treated with chemotherapy using CP.
Keyphrases
- oxidative stress
- diabetic rats
- ischemia reperfusion injury
- low dose
- high dose
- dna damage
- induced apoptosis
- locally advanced
- mouse model
- adverse drug
- endoplasmic reticulum stress
- drug induced
- emergency department
- radiation therapy
- cell cycle arrest
- cell proliferation
- electronic health record
- pi k akt
- heat shock protein