Timing of SARS-CoV-2 Vaccination Matters in People With Multiple Sclerosis on Pulsed Anti-CD20 Treatment.

Christina WoopenMarie DunscheRocco HaaseCatarina RaposoRosetta PedottiKatja AkgünTjalf Ziemssen

Published in: Neurology(R) neuroimmunology & neuroinflammation (2022)

Delaying BCDT is currently discussed as a strategy to optimize humoral responses to SARS-CoV-2 vaccination. However, T cells represent an important line of defense against SARS-CoV-2 infection as well, especially in light of emerging variants of concern. We observed enhanced CD4 and CD8 T-cellular responses in pwMS receiving vaccination at early time points after their last BCDT cycle. These data may influence clinical decision making with respect to vaccination strategies in patients receiving BCDT.

Keyphrases

sars cov
multiple sclerosis
respiratory syndrome coronavirus
decision making
nk cells
copy number
electronic health record
coronavirus disease