Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia.

Claire E Pillsbury Jodi Dougan Jennifer L Rabe Jairo A Fonseca Chengjing Zhou Alyssa N Evans Hasan Abukharma Ona Ichoku Gloria Gonzalez-Flamenco Sunita I Park Ahmed A Abdulrahman Deborah DeRyckere Sharon M Castellino Sarwish Rafiq Solomon Langermann Linda N Liu Curtis J Henry Christopher C Porter

Published in: Cancer research communications (2023)

We demonstrate that Sig15 is overexpressed in hematologic malignancies driven by NFκB, is required for immune evasion in a mouse model of leukemia, and, for the first time, that it circulates at high levels in the plasma of children with leukemia.

Keyphrases

acute lymphoblastic leukemia
mouse model
acute myeloid leukemia
bone marrow
allogeneic hematopoietic stem cell transplantation
signaling pathway
young adults
lps induced
oxidative stress
pi k akt
nuclear factor
inflammatory response
cell proliferation