Evidence for Shared Genetic Aetiology Between Schizophrenia, Cardiometabolic, and Inflammation-Related Traits: Genetic Correlation and Colocalization Analyses.

Benjamin I PerryNicholas BowkerStephen Burgess Nicholas J WarehamRachel UpthegrovePeter B JonesClaudia Langenberg Golam M Khandaker

Published in: Schizophrenia bulletin open (2022)

LDSC may lead to downwardly-biased genetic correlation estimates between schizophrenia, cardiometabolic, and inflammation-related traits. Common genetic aetiology for these traits could be confined to lower-frequency common variants and involve opposing mechanisms. Genes related to BDNF and glucose transport amongst others may partly explain the comorbidity between schizophrenia and cardiometabolic disorders.

Keyphrases

genome wide
copy number
bipolar disorder
dna methylation
oxidative stress
gene expression
skeletal muscle
transcription factor
insulin resistance
drug induced