Conception and Evaluation of Fluorescent Phosphine-Gold Complexes: From Synthesis to in vivo Investigations.
Benjamin RousselleAurélie MassotMalorie PrivatLucile DondaineAudrey TrommenschlagerFlorence BouyerJérôme BayardonFrançois GhiringhelliAli BettaiebChristine GozeCatherine PaulRaluca Malacea-KabbaraEwen BodioPublished in: ChemMedChem (2022)
A phosphine gold(I) and phosphine-phosphonium gold(I) complexes bearing a fluorescent coumarin moiety were synthesized and characterized. Both complexes displayed interesting photophysical properties: good molar absorption coefficient, good quantum yield of fluorescence, and ability to be tracked in vitro thanks to two-photon imaging. Their in vitro and in vivo biological properties were evaluated onto cancer cell lines both human and murine and into CT26 tumor-bearing BALB/c mice. They displayed moderate to strong antiproliferative properties and the phosphine-phosphonium gold(I) complex induced significant in vivo anti-cancer effect.
Keyphrases
- living cells
- silver nanoparticles
- ionic liquid
- quantum dots
- endothelial cells
- fluorescent probe
- computed tomography
- high resolution
- squamous cell carcinoma
- single molecule
- energy transfer
- type diabetes
- drug induced
- label free
- image quality
- insulin resistance
- skeletal muscle
- metabolic syndrome
- magnetic resonance
- positron emission tomography
- squamous cell
- mass spectrometry
- diffusion weighted imaging