Confined placental mosaicism of trisomy 6 detected through genome-wide NIPT was associated with placental abruption.

Miyuki NishiyamaSeiji WadaFuyuki HasegawaYohji UeharaMamoru OzakiKenichiro HataYushi ItoHaruhiko Sago

Published in: Clinical case reports (2021)

Confined placental mosaicism (CPM) leads to discordant noninvasive prenatal testing (NIPT) results. We describe a very rare case of CPM of trisomy 6 detected through genome-wide NIPT. This case was associated with placental abruption, which might suggest an association between certain types of CPM detected by NIPT and pregnancy complications.

Keyphrases

genome wide
rare case
dna methylation
pregnant women
copy number
risk factors
gene expression
preterm birth