Slack K+ channels confer protection against myocardial ischemia/reperfusion injury.

Anna RoslanKatharina PaulusJiaqi YangLucas MattHelmut BischofNatalie LängstSophia SchanzAnnika LuczakMelanie Cruz SantosSandra BurgstallerDavid SkrabakNadja I BorkRoland MalliAchim SchmidtkoMeinrad GawazViacheslav O NikolaevPeter RuthRebekka EhingerRobert Lukowski

Published in: Cardiovascular research (2024)

Collectively, our study provides evidence for Slack's crucial involvement in the ion homeostasis of no or low O2-stressed CMs. Thereby, Slack activity opposes the I/R-induced fatal Ca2+-uptake to CMs supporting the cardioprotective signaling widely attributed to mitoKATP function.

Keyphrases

ischemia reperfusion injury
oxidative stress
high glucose
diabetic rats
left ventricular
heart failure
endothelial cells