The role of gene-ambient air pollution interactions in paediatric asthma.
Jelte KelchtermansHakon HakonarsonPublished in: European respiratory review : an official journal of the European Respiratory Society (2022)
Globally, asthma prevention and treatment remain a challenge. Ambient air pollution (AAP) is an environmental risk factor of special interest in asthma research. AAP is poorly defined and has been subdivided either by the origin of the air pollution or by the specific bioactive compounds. The link between AAP exposure and asthma exacerbations is well established and has been extensively reviewed. In this narrative review, we discuss the specific genetic variants that have been associated with increased AAP sensitivity and impact in paediatric asthma. We highlight the relative importance of variants associated with genes with a role in oxidant defences and the nuclear factor-κB pathway supporting a potential central role for these pathways in AAP sensitivity.
Keyphrases
- air pollution
- lung function
- chronic obstructive pulmonary disease
- particulate matter
- nuclear factor
- allergic rhinitis
- cystic fibrosis
- intensive care unit
- emergency department
- genome wide
- risk factors
- toll like receptor
- gene expression
- immune response
- multidrug resistant
- human health
- genome wide identification
- climate change
- risk assessment
- genome wide analysis