Adipokine Resistin Levels at Time of Pediatric Crohn Disease Diagnosis Predict Escalation to Biologic Therapy.
Jacob A KurowskiJean-Paul AchkarRishi GuptaIulia BarburTracey L BonfieldSarah WorleyErick M RemerClaudio FiocchiSatish E ViswanathMarsha H KayPublished in: Inflammatory bowel diseases (2022)
Serum resistin levels at diagnosis of pediatric CD predict the escalation to biologic therapy at 12 months, independent of VAT volumes. Resistin and PAI-1 levels significantly improved in patients with CD after treatment using biologics compared with those not on biologics. These results suggest the utility of resistin as a predictive biomarker in pediatric CD.