Beneficial normalization of cardiac repolarization by carnitine in transgenic SQT1 rabbit models.

Ilona BodiLea MettkeKonstantin MichaelidesTibor HornyikStefan MeierSaranda NimaniStefanie Perez-FelizIbrahim El-BattrawyHeiko BuggerManfred ZehenderMichael BrunnerJordi HeijmanKatja E Odening

Published in: Cardiovascular research (2024)

L-Carnitine/C16-Carnitine prolong/normalize QT and whole heart/cellular APD in SQT1 rabbits. These beneficial effects are mediated by acute effects on IKr. L-Carnitine may serve as potential future QT-normalizing, anti-arrhythmic therapy in SQT1.

Keyphrases

drug induced
liver failure
heart failure
intensive care unit
atrial fibrillation
risk assessment
human health
climate change
bone marrow
mechanical ventilation