4-Aminopyridine: a pan voltage-gated potassium channel inhibitor that enhances Kv 7.4 currents and inhibits noradrenaline-mediated contraction of rat mesenteric small arteries.

Makhala M KhammySukhan KimBo Hjorth BentzenSoojung LeeInyeong ChoiChristian AalkjaerThomas Andrew Jepps

Published in: British journal of pharmacology (2018)

These data show that 4-AP is able to relax NA-preconstricted rat mesenteric arteries by enhancing the activity of Kv 7.4 and BKCa channels and attenuating NA-mediated signalling.

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