Suppressive myeloid cells are expanded by biliary tract cancer-derived cytokines in vitro and associate with aggressive disease.

Michael B WareMohammad Y ZaidiJennifer YangMichael K TurgeonAlyssa KrasinskasThomas A MaceKaitlin KeenanMatthew R FarrenAmanda N RuggieriYiman LiChao ZhangZhengjia ChenGregory S YoungOmar ElnaggarZheng CheShishir K MaithelTanios Bekaii-SaabBassel El-RayesGregory B Lesinski

Published in: British journal of cancer (2020)

BTC-derived factors promote suppressive myeloid cell expansion, and higher numbers of CD33+S100a9+ cells in resectable BTC tumours correlates with more aggressive disease.

Keyphrases

induced apoptosis
cell cycle arrest
bone marrow
acute myeloid leukemia
endoplasmic reticulum stress
squamous cell carcinoma
papillary thyroid
stem cells
cell death
single cell
oxidative stress
mesenchymal stem cells
immune response
cell therapy
cell proliferation
young adults
locally advanced